PUBLICATIONS
Olaris publishes in special Non-Uniform Sampling issue of Magnetic Resonance in Chemistry
October 28, 2020
Dr. Elizabeth O'Day and Leslie Hoyt's paper on discusses the opportunity for NUS NMR metabolite in-vitro diagnostics- key tools that can accelerate the goals of precision medicine.
The ease of sample preparation, quantification of metabolite levels for overlapping peaks often found in patient samples, and reproducibility afforded by NMR can be used to develop metabolite based diagnostics with NUS. This may serve to reduce the long acquisition time associated with NMR.
Olaris Presents NMR-based Metabolomics Research at ENC!
March 09, 2020
Olaris' will be presenting a poster and giving a talk at the ENC! The Experimental NMR Conference features innovative research in NMR spectroscopy and Olaris is very excited to share our recent studies on the power of NUS 13C 1H HSQC NMR. See the poster below.
Olaris Announces Findings from Exploratory Analysis of Biomarkers that Predict Patient Responsiveness to Trastuzumab Therapy
March 02, 2020
Olaris’ metabolite profiling platform and machine learning algorithms have the potential to accurately indicate whether HER2-positive metastatic breast cancer patients will respond to trastuzumab therapy.
Olaris Head of Metabolite Discovery, Dr. Bo Zhang, had a paper come out in the Journal of Proteome Research
February 28, 2020
Research Dr. Zhang contributed to was published in the Journal of Proteome Research. They developed a method to better identify lipid molecules through 2D NMR and COLMAR Lipids Web Server.
Olaris Presents a Poster at the San Antonio Breast Cancer Symposium!
December 12, 2019
Olaris is thrilled to present at the SABCS! We are excited to learn from the world's top breast cancer oncologists and share the results of our recent study, "Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer." Learn more about our findings here.
Dr. Bo Zhang, Olaris Head of Metabolite Discovery, had a paper come out in Analytical Chemistry!
December 11, 2019
"Accurate and Efficient Determination of Unknown Metabolites in Metabolomics by NMR-Based Molecular Motif Identification" discusses the new SUMMIT method to identify chemical classes of metabolites, a critical tool in understanding patient health and disease. Read the paper here!
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Olaris Metabolite Scientist, Dr. Chandra Honrao, had a paper come out in Nature Research!
November 29, 2019
We are so proud of Dr. Honrao for his work in helping to discover a new antibiotic for Gram-negative pathogens, a notoriously difficult pathogen to target. In fact, the last development in antibiotics for Gram-negative bacteria was in the 1960s. The exciting discovery has the potential to be developed into new therapeutics. Read the paper here!
Paper: Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells
October 15, 2018
Cancer cells have altered bioenergetics, which contributes to their ability to proliferate, survive in unusual microenvironments, and invade other tissues. Changes in glucose metabolism can have pleomorphic effects on tumor cells. To investigate potential mechanisms responsible for the increased malignancy associated with altered glucose metabolism, we used Olaris technology to identify glucose metabolites differentially produced in a highly malignant human triple-negative breast cancer (TNBC) cell line (BPLER) and a less malignant isogenic TNBC cell line (HMLER).
